{"href":"https://api.simplecast.com/oembed?url=https%3A%2F%2Famindr.com%2Fepisodes%2F298-understanding-apoe-and-alzheimers-disease-june-2022-69fK8iUK","width":444,"version":"1.0","type":"rich","title":"298 - Understanding APOE and Alzheimer's Disease: June 2022","thumbnail_width":300,"thumbnail_url":"https://image.simplecastcdn.com/images/9a8ef428-72db-47cb-a5cb-a6a258a13785/1039af20-dd19-442b-aebf-fd9be3d83192/slide14.jpg","thumbnail_height":300,"provider_url":"https://simplecast.com","provider_name":"Simplecast","html":"<iframe src=\"https://player.simplecast.com/952cbf13-0c36-4eee-8304-fb70ac211f49\" height=\"200\" width=\"100%\" title=\"298 - Understanding APOE and Alzheimer&apos;s Disease: June 2022\" frameborder=\"0\" scrolling=\"no\"></iframe>","height":200,"description":"Approximately, one in every five people you know, has a copy of the largest genetic risk allele for late-onset Alzheimer's disease called apolipoprotein E4 (APOE). In this episode, Cassi discusses papers from June 2022 about APOE and covers human subjects research, pathology related to E4 risk, and mechanisms. \n\nSections in this episode: \nHuman Subjects Research (2:52) \nAD Pathology (11:19) \nMechanism (15:12)  \nTargeting Memory Impairment with Genetic Manipulation (10:51) \nTargeting Synaptic Function (15:17) "}