{"href":"https://api.simplecast.com/oembed?url=https%3A%2F%2Famindr.com%2Fepisodes%2F309-vascular-changes-in-alzheimers-disease-august-2022-mliVPlhj","width":444,"version":"1.0","type":"rich","title":"309 - Vascular Changes in Alzheimer's Disease: August 2022","thumbnail_width":300,"thumbnail_url":"https://image.simplecastcdn.com/images/9a8ef428-72db-47cb-a5cb-a6a258a13785/b1f40600-ebfb-4e59-885f-34b30d2b7d0a/slide6-2.jpg","thumbnail_height":300,"provider_url":"https://simplecast.com","provider_name":"Simplecast","html":"<iframe src=\"https://player.simplecast.com/05cbcd16-4643-4ecc-a9d1-7e8708d1ec77\" height=\"200\" width=\"100%\" title=\"309 - Vascular Changes in Alzheimer&apos;s Disease: August 2022\" frameborder=\"0\" scrolling=\"no\"></iframe>","height":200,"description":"After a bit of a break, Elyn is excited to be back with the latest in the field of vascular contributions to Alzheimer disease. With the current (and constant) controversy in the field about targeting amyloid as a disease-modifying therapy, perhaps it's time we turned to a new target: the vasculature. Tune in for an overview of papers published in August 2022, including lots of nitric oxide signalling, animal model characterization, white matter hyperintensities and their relevant associations, and much more! \n\nSections in this episode: \nVascular Remodeling and Nitric Oxide Signaling (3:36) \nWhite Matter Hyperintensities and Enlarged Perivascular Spaces (9:03) \nMechanistic Insight in the Cerebrovascular Endothelium (15:22) \nOverlap with Other Diseases and Treatment Avenues (20:22) "}