{"href":"https://api.simplecast.com/oembed?url=https%3A%2F%2Famindr.com%2Fepisodes%2F330-vascular-changes-in-alzheimers-disease-january-2023-vFViEC9t","width":444,"version":"1.0","type":"rich","title":"330 - Vascular Changes in Alzheimer's Disease: January 2023","thumbnail_width":300,"thumbnail_url":"https://image.simplecastcdn.com/images/9a8ef428-72db-47cb-a5cb-a6a258a13785/5c080c82-5e23-47ff-ab45-c5944b207463/slide2-3.jpg","thumbnail_height":300,"provider_url":"https://simplecast.com","provider_name":"Simplecast","html":"<iframe src=\"https://player.simplecast.com/439d4997-36ad-491c-b325-2c7d0b8303b5\" height=\"200\" width=\"100%\" title=\"330 - Vascular Changes in Alzheimer&apos;s Disease: January 2023\" frameborder=\"0\" scrolling=\"no\"></iframe>","height":200,"description":"Elyn's back with more insight from the field on how blood vessel health impacts brain health. Tune in for a journey through mechanisms underlying increased risk from \"vascular risk factors\" like hypertension, diabetes, and atrial fibrillation, lots of neuroimaging studies providing clinical insights, and several interesting novel therapeutic avenues. If you weren't already convinced that the vasculature is relevant in the context of AD, you sure will be after this episode! \n\nSections in this episode: \nCerebral blood flow and hypoperfusion (4:08) \nMore clinical insights (10:53) \nBlood-brain barrier and amyloid-endothelial cell interactions (19:52) \nTherapeutic avenues targeting the vasculature (27:12) "}